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KMID : 0613820120220020281
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Journal of Life Science
2012 Volume.22 No. 2 p.281 ~ p.284
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Expression of the cAMP Phosphodiesterase 7A1 Gene by Endoplasmic Reticulum Stress
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Kwon Ki-Sang
Kwon Young-Sook
Kwon O-Yu
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Abstract
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This study demonstrated that upregulation of gene expression of endoplasmic reticulum (ER) stress chaperones (Bip, ERp29, calnexin, and PDI), ER stress sensors (PERK, ATF6, and Ire1), and cAMP phosphodiesterase 7A1 (cAMP PDE7A1) was induced by ER stresses in FRTL5 cells. While removing A23187 from the culture medium restored upregulation of cAMP PDE7A1 gene expression, removal of thapsigargin did not recover its expression. In addition, cAMP PDE7A1 gene expression was strongly inhibited by treatment with A23187 combined with thyroid stimulating hormone (TSH). The results are the first to show that ER stress induces cAMP PDE7A1 gene expression.
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KEYWORD
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cAMP phosphodiesterase 7A1 (cAMP PDE7A1), endoplasmic reticulum (ER) stress, ER chaperone
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